A 7-amino acid epitope peptide that corresponds to a site on the second extracellular loop of the AT1 receptor that is recognized by autoantibodies from women with preeclampsia. This 7-amino acid peptide can neutralize AT1-AA and thereby prevent autoantibodyinduced sFlt-1 production in placental explants and cultured trophoblast cells.

Zhou C.C. et al. Hypertension. 2008;51:1010

Short, overlapping peptides corresponding to the second extracellular loop of the AT1 receptor were prepared. These peptides were exposed to affinity-purified antibody preparations. We tested the effect on the spontaneous beating rate of neonatal rat cardiomyocytes. The sequence AFHYESQ abolished the response.

Wallukat G., et al. J Clin Invest. 1999 April 1; 103(7): 945–952.