Substance P [Tyr8] - I-125 Labeled

Tracer	¹²⁵I-[Tyr⁸]-Substance P
Catalog #	T-061-10
Standard Size	10 µCi
Sequence	Arg - Pro - Lys - Pro - Gln - Gln - Phe - Tyr - Gly - Leu - Met - NH2
Species	Human, Rat, Mouse
Standard	[Tyr8]-Substance P
Reconstitution	Rehydrate with 1ml of distilled water (minimum) just before use. Then further dilute to desired concentration with any aqueous buffer. Repeated freezing and thawing is not recommended.
Storage Condition	-20°C or lower
Specific_activity	1211.48 Ci/mmole
Instruction	Instruction for possession, Handling and Use of Radioactive Material: This radioactive material shall only be received, acquired, possessed and used by physicians, Veterinarians and investigators in laboratories or hospitals for in-vitro laboratory tests. Its use shall not involve internal or external administration of the material and radiation therefrom to human being or animals. Its receipt, acquisition, possession, use and transfer are subject to regulations and general license requirements of the U.S. Nuclear Regulatory Commission or of a State with which the Commission has entered into an agreement of the exercise of regulatory authority.
Precaution	Precautions in Handling Radioactive Material: The user should store the by-product material, until used, in the original shipping container or in a container providing equivalent radiation protection. There should be no drinking, eating or smoking while radioactive material is being handled. Hands should be covered with gloves during and thoroughly washed after the handling of radioactive material. When handling radioactive material, do not pipette by mouth. Spills should be wiped up quickly and thoroughly, and contaminant material added to the radioactive waste matter. Persons under 18 should not be permitted to handle radioactive material or enter radioactive areas.
Disposal	Radioactive waste should be disposed of in compliance with Federal, State, and local Government regulations.
Disclaimer	THIS PACKAGE CONFORMS TO THE CONDITIONS AND LIMITATIONS SPECIFIED IN 49 CFR173.421 FOR EXPECTED RADIOACTIVE MATERIAL LIMITED QUANTITY, N.O.S. UN2910.

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Links to publications that use this product:

Caviedes-Bucheli et al. Substance P receptor expression in healthy and inflamed human pulp tissue
Int Endod J. 2007 Feb;40(2):106-11.

Hua et al. Left vagal stimulation induces dynorphin release and suppresses substance P release from the rat thoracic spinal cord during cardiac ischemia.
Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1468-77.

Williams et al. Direct injection of substance P-antisense oligonucleotide into the feline NTS modifies the cardiovascular responses to ergoreceptor but not baroreceptor afferent input.
Brain Res. 2003 Feb 14;963(1-2):26-42.