Metastin / Kiss-1 / GPR54 / AXOR12

Catalog #	048-56
Standard Size	200 µg
Sequence	Tyr - Asn - Trp - Asn - Ser - Phe - Gly - Leu - Arg - Phe - NH2
Species	Human
M.W	1302.44
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 200µg of NET peptide.
HPLC Analysis	Purity ≥95%
Additional articles	For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

 

Manuel A. Ricu, Victor D. Ramirez, Alfonso H. Paredes, and Hernan E. Lara. Evidence for a Celiac Ganglion-Ovarian Kisspeptin Neural Network in the Rat: Intraovarian Anti-Kisspeptin Delays Vaginal Opening and Alters Estrous Cyclicity. 
Endocrinology. 2012 Oct;153(10):4966-77. Epub 2012 Aug 6.

Pielecka-Fortuna et al. Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol.
Endocrinology. 2008 Apr;149(4):1979-86.

Suzuki et al. Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.
Anim Reprod Sci. 2008 Jan 30;103(3-4):360-5.

Tenenbaum-Rakover et al. Neuroendocrine Phenotype Analysis in Five Patients with Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of GPR54
J Clin Endocrinol Metab. 2007 Mar;92(3):1137-44.

Greives et al. Environmental Control of Kisspeptin: Implications for Seasonal Reproduction
Endocrinology. 2007 Mar;148(3):1158-66.

Mason et al. Suppression of kisspeptin expression and gonadotropic axis sensitivity following exposure to inhibitory day lengths in female Siberian hamsters
Horm Behav. 2007 Nov;52(4):492-8. 

Sun et al. Characteristic of hypothalamic kisspeptin expression in the pubertal development of precocious female rats
Neurosci Lett. 2007 Jun 8;420(1):12-7.

Pompolo et al. Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain.
Endocrinology. 2006 Feb;147(2):804-10.

Castellano et al. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats.
Diabetes. 2006 Sep;55(9):2602-10.

Arai et al. Cancer metastasis-suppressing peptide metastin upregulates excitatory synaptic transmission in hippocampal dentate granule cells.
J Neurophysiol. 2005 Nov;94(5):3648-52. 

Semple et al. Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.
J Clin Endocrinol Metab. 2005 Mar;90(3):1849-55.

 

For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.