Nociceptin/Orphan FQ RIA Kit

Orphanin FQ {Nociceptin} Prohormone Schematic (Human)

Nociceptin Sequence Comparison

Normal Plasma Peptide/Protein Levels

Protocol	Assay Protocol (PDF)
Sample Preparation	Blood collection Plasma extraction Tissue extraction CSF extraction
Catalog #	RK-021-55
Standard Size	125 RIA tubes
Radioactivity	This kit contains 1.5 µCi of Iodine 125
Range	1-128 pg/tube in 100µl Standard Solution = 10-1280 pg/ml
Lowest Detection Limit	51 pg/ml
Cross Reactivity	Peptide % Cross-reactivity  Nociceptin (Orphanin FQ)  100  Met-Enkephalin  0  Dynorphin A (Porcine)  0  b-Endorphin (Human)  0
Sequence	Phe - Gly - Gly - Phe - Thr - Gly - Ala - Arg - Lys - Ser - Ala - Arg - Lys - Leu - Ala - Asn - Gln

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this kit:

Lufty et al. Alterations in the level of OFQ/N-IR in rat brain regions by cocaine.
Neuropharmacology. 2008 Aug;55(2):198-203.

Williams et al. Nociceptin and urotensin-II concentrations in critically ill patients with sepsis.
Br J Anaesth. 2008 Jun;100(6):810-4.

Maeshiro et al. Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis.
Surg Today. 2008;38(2):130-4.

Ertsey et al. Plasma nociceptin levels are reduced in migraine without aura.
Cephalalgia. 2005 Apr;25(4):261-6.

Ertsey et al. Circulating nociceptin levels during the cluster headache period.
Cephalalgia. 2004 Apr;24(4):280-3

Horvath et al. Rising plasma nociceptin level during development of HCC: a case report.
World J Gastroenterol. 2004 Jan;10(1):152-4.

Szalay et al. Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma.
World J Gastroenterol. 2004 Jan;10(1):42-5.

Ko et al. Quantitative analysis of nociceptin in blood of patients with acute and chronic pain.
Neuroreport. 2002 Sep 16;13(13):1631-3.

Sun et al. Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain
Neurosci Lett. 2001 Sep 21;311(1):13-6.

Armstead. NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury
Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2188-95.

Kulkarni et al. Superoxide Generation Links Nociceptin/Orphanin FQ (NOC/oFQ) Release to Impaired N-Methyl-D-Aspartate Cerebrovasodilation After Brain Injury
Stroke. 2000 Aug;31(8):1990-6.

Yuan et al. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats.
Brain Res. 1999 May 1;826(2):330-4.

Szalay F, et al. World J Gastroenterol 2004; 10 (1):42-45 / Armstead - AJP - Heart Circul. Phys. - Vol. 279 - Issue 5 - H2188-H2195 - November 2000