Corticotropin Releasing Factor (CRF)

Catalog #	019-06
Standard Size	200 µg
Sequence	Ser - Glu - Glu - Pro - Pro - Ile - Ser - Leu - Asp - Leu - Thr - Phe - His - Leu - Leu - Arg - Glu - Val - Leu - Glu - Met - Ala - Arg - Ala - Glu - Gln - Leu - Ala - Gln - Gln - Ala - His - Ser - Asn - Arg - Lys - Leu - Met - Glu - Ile - Ile - NH2
Species	Human, Rat, Mouse, Canine
M.W	4757.52
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 200µg of NET peptide.
HPLC Analysis	Purity ≥95%
Additional articles	For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

LaBerge et al. Postnatal expression of corticotropin releasing factor (CRF) in rat urinary bladder.
Auton Neurosci. 2008 Aug 18;141(1-2):83-93.

Hazard et al. Characterization of CRF, AVT, and ACTH cDNA and pituitary-adrenal axis function in Japanese quail divergently selected for tonic immobility
Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1421-9.

Lebrethon et al. Effects of In Vivo and In Vitro Administration of Ghrelin, Leptin and Neuropeptide Mediators on Pulsatile Gonadotrophin-Releasing Hormone Secretion from Male Rat Hypothalamus Before and After Puberty
J Neuroendocrinol. 2007 Mar;19(3):181-8.

Cao et al. Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway.
Mol Pharmacol. 2006 Mar;69(3):998-1006.

Holmes et al. Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases.
J Neurochem. 2006 Feb;96(4):934-49.

Weitemier et al. Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice.
Neuroscience. 2006;137(4):1439-45. 

Baker et al. Neuropeptide W Acts in Brain to Control Prolactin, Corticosterone, and Growth Hormone Release
Endocrinology. 2003 Jul;144(7):2816-21.

Bachtell et al. The Edinger-Westphal–Lateral Septum Urocortin Pathway and Its Relationship to Alcohol Consumption
J Neurosci. 2003 Mar 15;23(6):2477-87. 

Samson et al. Hypocretin/orexin suppresses corticotroph responsiveness in vitro.
Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1140-5. 

Correia et al. Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure.
Hypertension. 2001 Sep;38(3):384-8.

Wang et al. Feeding inhibition by urocortin in the rat hypothalamic paraventricular nucleus.
Am J Physiol Regul Integr Comp Physiol. 2001 Feb;280(2):R473-80.

For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.