Adrenomedullin

Normal Plasma Peptide/Protein Levels

Adrenomedullin-5 Porcine

Catalog #	010-08
Standard Size	100 µg
Sequence	Tyr - Arg - Gln - Ser - Met - Asn - Gln - Gly - Ser - Arg - Ser - Thr - Gly - Cys - Arg - Phe - Gly - Thr - Cys - Thr - Met - Gln - Lys - Leu - Ala - His - Gln - Ile - Tyr - Gln - Phe - Thr - Asp - Lys - Asp - Lys - Asp - Gly - Met - Ala - Pro - Arg - Asn - Lys - Ile - Ser - Pro - Gln - Gly - Tyr - NH2 Disulfide bridge between Cys14 & Cys19
Species	Rat
M.W	5729.49
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C. For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.
Content	The contents of this vial have been accurately determined to contain 100µg of NET peptide.
HPLC Analysis	Purity ¡Ý 95%

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Links to publications that use this product:

Zeng et al. Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats.
Peptides. 2009 Feb;30(2):391-9. 

Balat et al. Malon dialdehyde, nitrite and adrenomedullin levels in patients with premenstrual syndrome
Arch Gynecol Obstet. 2007 May;275(5):361-5.

Pan et al. The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation
Peptides. 2007 Apr;28(4):900-9.

Yılmaz et al. Increased Levels of Nitric Oxide, Cortisol and Adrenomedullin in Patients with Chronic Schizophrenia
Med Princ Pract. 2007;16(2):137-41.

Balat et al. Adrenomedullin and total nitrite levels in children with familial Mediterranean fever.
J Paediatr Child Health. 2006 May;42(5):240-3.

Ren et al. Intermedin 1-53 in central nervous system elevates arterial blood pressure in rats.
Peptides. 2006 Jan;27(1):74-9.

Pan et al. Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2.
Peptides. 2005 Sep;26(9):1640-6.

Taylor et al. Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake.
Am J Physiol Regul Integr Comp Physiol. 2005 Apr;288(4):R919-27. 

Jiang et al. Effects of adrenomedullin on aldosterone-induced cell proliferation in rat cardiac fibroblasts.
Biochim Biophys Acta. 2004 Nov 5;1690(3):265-75.

Jiang et al. Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone.
J Hypertens. 2004 Oct;22(10):1953-61.

Luodonpää et al. Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin II in conscious rats.
Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1085-92.

Huang et al. Effects of adrenomedullin, C-type natriuretic peptide, and parathyroid hormone-related peptide on calcification in cultured rat vascular smooth muscle cells.
J Cardiovasc Pharmacol. 2003 Jul;42(1):89-97.

Follwell et al. Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms.
Am J Physiol Regul Integr Comp Physiol. 2002 Dec;283(6):R1293-302.

Ladoux et al. Coordinated Up-regulation by Hypoxia of Adrenomedullin and One of Its Putative Receptors (RDC-1) in Cells of the Rat Blood-Brain Barrier*
J Biol Chem. 2000 Dec 22;275(51):39914-9.

Samson et al. Adrenomedullin Inhibits Salt Appetite.
Endocrinology. 1997 Feb;138(2):613-6.