Adrenomedullin (Human)

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Adrenomedullin (Human)

Catalog#	Standard size	Price	Order
010-01	100 µg	$200.00

Catalog #	010-01
Standard Size	100 µg
Sequence	Tyr - Arg - Gln - Ser - Met - Asn - Asn - Phe - Gln - Gly - Leu - Arg - Ser - Phe - Gly - Cys - Arg - Phe - Gly - Thr - Cys - Thr - Val - Gln - Lys - Leu - Ala - His - Gln - Ile - Tyr - Gln - Phe - Thr - Asp - Lys - Asp - Lys - Asp - Asn - Val - Ala - Pro - Arg - Ser - Lys - Ile - Ser - Pro - Gln - Gly - Tyr - NH2 Disulfide Bridge: Cys16 - Cys21
Species	Human
M.W	6028.82
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C. For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 100µg of NET peptide.
HPLC Analysis	Purity > 95%

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Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

Wang L, Li C, Chen Y, Dong S, Chen X, Zhou Y. Poly(lactic-co-glycolic) Acid/Nanohydroxyapatite Scaffold Containing Chitosan Microspheres with Adrenomedullin Delivery for Modulation Activity of Osteoblasts and Vascular Endothelial Cells.
BioMed Research International. 2013;2013:1-13.

Deng, Boya et al., Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin.
Journal of Experimental & Clinical Cancer Research, March 9, 2012

Pérez-Castells, J., Martín-Santamaría, S., Nieto, L., et al, Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules.
Biopolymers. 2012 Jan;97(1):45-53. doi: 10.1002/bip.21700. Epub 2011 Aug 9.

Sackett et al. Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function.
Endocrinology. 2008 Jun;149(6):2888-98.

Allaker et al. Interaction ofadrenomedullin and calcitonin gene-related peptide with the periodontal pathogen Porphyromonas gingivalis
FEMS Immunol Med Microbiol. 2007 Feb;49(1):91-7.

Allaker et al. Mechanisms of adrenomedullin antimicrobial action.
Peptides. 2006 Apr;27(4):661-6.

Zudaire et al. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
Am J Pathol. 2006 Jan;168(1):280-91.

Ogawa et al. Neuroendocrine profiling of humans receiving cardiac allografts.
J Heart Lung Transplant. 2005 Aug;24(8):1046-54.

Linscheid et al. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue.
Endocrinology. 2005 Jun;146(6):2699-708.

Yin et al. Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling.
Hypertension. 2004 Jan;43(1):109-16.

Kapas et al. Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes.
J Invest Dermatol. 2001 Aug;117(2):353-9.

Thomson et al. Autocrine role of adrenomedullin in the human adrenal cortex.
J Endocrinol. 2001 Jul;170(1):259-65.

Pio et al. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners.
J Biol Chem. 2001 Apr 13;276(15):12292-300.

Yousufzai et al. Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle.
Invest Ophthalmol Vis Sci. 1999 Dec;40(13):3245-53.

Jougasaki et al. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin.
Hypertension. 1998 Nov;32(5):917-22.

Lisy et al. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin.
Am J Physiol. 1998 Sep;275(3 Pt 2):F410-4.