Endothelin and Endothelin-like Peptides

Normal Plasma Peptide/Protein Levels

Catalog #	023-38
Standard Size	200 µg
Sequence	(N - cis - 2 6 - Dimethylpiperidino - carbonyl - L - gamma - MeLeu - D - Trp(COOMe) - D - Nle - (ONa)
M.W	663.7
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Insoluble in water. Rehydrate with 0.01% Ammonium Hydroxide in water (pH 8.0).
Storage Condition	Store peptide in DRY form at 0-5°C.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 200µg of NET peptide.
HPLC Analysis	Purity ≥98%
Additional articles	Light and heat sensitive For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.

Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

Juan et al. Endothelin-1 Regulates Adiponectin Gene Expression and Secretion in 3T3-L1 Adipocytes via Distinct Signaling Pathways
Endocrinology. 2007 Apr;148(4):1835-42.

Kwok et al. Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells
Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E648-52.

Juan et al. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes.
Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1146-52.

Liu et al. Prior antagonism of endothelin-1A receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke.
J Pharmacol Sci. 2004 Oct;96(2):177-87.

Piuhola et al. Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice
Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H112-8.

Beyer et al. Inotropic effects of endothelin-1: interaction with molsidomine and with BQ 610.
Hypertension. 1999;33:145-152

Hasdai et al. Enhanced Endothelin-B-Receptor–Mediated Vasoconstriction of Small Porcine Coronary Arteries in Diet-Induced Hypercholesterolemia
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2737-43.

Other Information:

ETA, IC50=572nM; ETB, IC50=45nM - T. Fukuroda et al., BBRC Vol 199, No. 3, 1461-1465 (1994).

Light and heat sensitive For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.