MT II (MC3/4R agonist)

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MT II (MC3/4R agonist)

Catalog#	Standard size	Price	Order
043-23	200 µg	$85.00

Catalog #	043-23
Standard Size	200 µg
Sequence	Ac - Nle - Asp - His - D - Phe - Arg - Trp - Lys - NH2 Amide Bridge: Asp3 - Lys8
M.W	1024.2
Mass Spec Analysis	Exhibits correct M.W.
Solubility	Before reconstitution, please allow 25 to 45 minutes for the lyophilized peptide to return to room temperature. Briefly vortex the Eppendorf tube to concentrate all material at the bottom of the tube. Gently open the cap and reconstitute the peptide to the desired concentration by adding a sterile, aqueous solution to the tube. Invert the tube 5 times by hand to ensure a homogeneous solution.
Storage Condition	Store peptide in DRY form at 0-5°C. For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.
Appearance	White powder
Content	The contents of this vial have been accurately determined to contain 200µg of NET peptide.
HPLC Analysis	Purity ≥95%

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Please click here or click the reference tab on the top to see more articles that use this product.

Links to publications that use this peptide:

Vaughan C.H. et al. Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis.
Brain Res. 2011 Sep 9;1411:17-27.

Shimakura et al. α-Melanocyte-stimulating hormone mediates melanin-concentrating hormone-induced anorexigenic action in goldfish
Horm Behav. 2008 Feb;53(2):323-8.

Fujimoto et al. Dmbx1 is essential in agouti-related protein action.
Proc Natl Acad Sci USA. 2007 Sep 25;104(39):15514-9.

Selkirk et al. Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells
Neuropharmacology. 2007 Feb;52(2):459-66.

Smith et al. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances
J Physiol. 2007 Jan 15;578(Pt 2):425-38.

Irani et al. Altered Hypothalamic Leptin, Insulin, and Melanocortin Binding Associated with Moderate-Fat Diet and Predisposition to Obesity
Endocrinology. 2007 Jan;148(1):310-6.

Keen-Rhinehart et al. MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake
Horm Behav. 2007 Dec;52(5):612-20.

Olszewski et al. alpha-Melanocyte stimulating hormone and ghrelin: Central interaction in feeding control
Peptides. 2007 Oct;28(10):2084-9.

Gotoh et al. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.
Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202-7.

Yang et al. Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript peptide.
J Neurochem. 2005 Feb;92(3):637-46.

Starowicz et al. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.
Neurosci Lett. 2004 Mar 25;358(2):79-82.

Lu et al. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses.
J Neurosci. 2003 Aug 27;23(21):7863-72.

Rahmouni et al. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin.
J Neurosci. 2003 Jul 9;23(14):5998-6004.

Hagan et al. Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade
Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R47-52.

Other Information:

Agonist of rat MC3-receptor (EC50=0.27±0.23nM) and mouse MC4-receptor (EC50=0.057±0.024nM) - Wei Fan et al., Nature 385, 165-168 (1997)