Description:
A selective inhibitor of ALK-4 (Activin/Nodal receptor), ALK-5 (TGF-type I receptor), and ALK-7 (nodal receptor). Only weakly inhibits ALK-1, -2, -3, and -6.
3-(6-METHYLPYRIDIN-2-YL)-1-PHENYLTHIOCARBAMOYL-4-QUINOLIN-4-YLPYRAZOLE
Ref: Tojo, M., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 96: 791-800, 2005.
CAS: 909910-43-6
