Description:

A selective inhibitor of the transforming growth factor-
(TGF-
) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and the related ALK4 and ALK7.

4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE

Ref: Laping et al. Inhibition of transforming growth factor (TGF)-
1-induced extracellular matrix with a novel inhibitor of the TGF-
type I receptor kinase activity: SB-431542. Mol.Pharmacol. 62 58, 2002.
       Inman et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-
superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 62 65, 2002.

CAS: 301836-41-9