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080-60A
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Purmorphamine
Catalog#
Standard size
Price
Order
080-60A
5 mg
$99.00
Novel Paradigm of Metabolic Regulation
Catalog #
080-60A
Family
Hedgehog Pathway
Standard Size
5 mg
Sequence
C31H32N6O2
M.W
520.6
Solubility
Soluble in DMSO at 10 mM.
Before reconstitution, we recommend a brief spin to drive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO.
Storage Condition
The powder is stable for at least 2 year if stored at -20 degree C. The dissolved compound is stable for at least 1 month at 4 degree C, but should be stored in aliquots at -20 degree C for longer term. Protect from light.
Appearance
Powder
HPLC Analysis
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Graphic Data
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Description:
Purmorphamine is an agonist of SMO (smoothened). This small molecule compound activates the hedgehog pathway by directly binding to SMO. It has been shown to induce osteogenesis of mesenchymal stem cells.
Ref: Wu, X., et al. 2004. Chem. Biol. 11: 1229;
Sinha, S. and Chen, J.K. 2006. Nat. Chem. Biol. 2: 29
Biological Activity:
In a cell-based assay measuring the activation of the Gli-1 reporter gene,
this compound gives EC50 of 1.0 uM.
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