Description:
CHIR99021 (CT99021) is a glycogen synthase kinase 3 (GSK3) inhibitor with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases CDKs) with 350-fold selectivity toward GSK-3 compared to CDKs.
Ref: Tighe A et al. BMC Cell Biol. 2007 Aug 14;8:34
Biological Activity:
In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives EC50 of 50 nM.
CAS No.: 252917-06-9