Links to publications that use this peptide:
Lerma-cabrera JM, Carvajal F, De la torre L, et al. Control of food intake by MC4-R signaling in the lateral hypothalamus, nucleus accumbens shell and ventral tegmental area: interactions with ethanol.
Behav Brain Res. 2012;234(1):51-60.
Bariohay B, Roux J, Tardivel C, Trouslard J, Jean A, Lebrun B. Brain-derived neurotrophic factor/tropomyosin-related kinase receptor type B signaling is a downstream effector of the brainstem melanocortin system in food intake control.
Endocrinology. 2009;150(6):2646-53.
Irani et al. Altered Hypothalamic Leptin, Insulin, and Melanocortin Binding Associated with Moderate-Fat Diet and Predisposition to Obesity
Endocrinology. 2007 Jan;148(1):310-6.
Ercil et al. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice.
Psychopharmacology (Berl). 2005 Jul;180(2):279-85.
Yang et al. Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript peptide.
J Neurochem. 2005 Feb;92(3):637-46.
Yang et al. Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of dopamine in tuberoinfundibular neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin.
Neuropharmacology. 2004 Dec;47(7):1070-80.
Chai BX, Neubig RR, Millhauser GL, et al. Inverse agonist activity of agouti and agouti-related protein.
Peptides. 2003;24(4):603-9.
Gao et al. Agonist-dependent internalization of the human melanocortin-4 receptors in human embryonic kidney 293 cells.
J Pharmacol Exp Ther. 2003 Dec;307(3):870-7.
Lu et al. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses.
J Neurosci. 2003 Aug 27;23(21):7863-72.
Hansen MJ, Morris MJ. Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat. Neuropharmacology. 2002;42(6):792-7. Other Information:
Potent and selective MC4 antagonist - Schioth, H. B. et al., Brit. J. of Pharmacol. 124. 75-82 (1998).
For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.