Links to publications that use this peptide:
Green et al. Roles of the bed nucleus of stria terminalis and of the amygdala in N/OFQ-mediated anxiety and HPA axis activation
Neuropeptides. 2007 Dec;41(6):399-410.
Gottlieb et al. Identification of Central Nervous System Sites Involved in the Water Diuresis Response Elicited By Central Microinjection of Nociceptin/Orphanin FQ in Conscious Rats Via c-Fos and Inducible cAMP Early Repressor Immunocytochemistry
J Neuroendocrinol. 2007 Jul;19(7):531-42.
Khroyan et al. Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents
Eur J Pharmacol. 2007 Mar 29;560(1):29-35.
Bomberg et al. Functional interaction between nociceptin/orphanin FQ and alpha-melanocyte-stimulating hormone in the regulation of feeding.
Peptides. 2006 Jul;27(7):1827-34.
Krowicki et al. Tonic nociceptinergic inputs to neurons in the hypothalamic paraventricular nucleus contribute to sympathetic vasomotor tone and water and electrolyte homeostasis in conscious rats.
J Pharmacol Exp Ther. 2006 Apr;317(1):446-53.
Ring et al. Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth.
J Neurobiol. 2006 Mar;66(4):361-77.
Armstead. Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury.
Eur J Pharmacol. 2006 Jan 4;529(1-3):129-35.
Slugg et al. Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance.
J Physiol. 2003 Aug 15;551(Pt 1):295-308.
Jia et al. Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel.
Br J Pharmacol. 2002 Feb;135(3):764-70.
Huang et al. Comparison of Pharmacological Activities of Buprenorphine and Norbuprenorphine: Norbuprenorphine Is a Potent Opioid Agonist
J Pharmacol Exp Ther. 2001 May;297(2):688-95.
Serhan et al. Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment: Inhibition by Aspirin-Triggered-15-Epi-Lipoxin A4
J Immunol. 2001 Mar 15;166(6):3650-4.
Yuan et al. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats.
Brain Res. 1999 May 1;826(2):330-4.
Other Information:
In conscious rats, intravenous infusion of Orphanin FQ produced a profound increase in urine flow rate and decrease in urinary sodium excretion - Meunier, J-C. et al., Nature 377, 532-535 (1995) , Reinscheid, R.K. et al., Science 270, 792-794 (1995)
For best results and reproducibility, rehydrate peptide just before use. Do not attempt to weigh out smaller portions. Do not refreeze any unused portions.