The HMGI family of proteins are architectural transcription factors and consists of three members, HMGIC, HMGI and HMGI(Y). Recent research results implicate HMGIC as playing a central role in obesity. Mice with a partial or complete deficiency in HMGIC expression resisted diet and leptin induced obesity. 

Anand A. and Chada K. In vivo modulation of HMGIC reduces obesity. Nature Genetics 24, 377-380 (2000)