WKYMVM
An agonist for the orphan receptor chemoattractant receptor FPRL1 and FPRL2.
Different chemoattractants induce leukocyte infiltration and activation
through binding to G protein-coupled receptor. FPRL1, and FPRL2 belong to the
N-formyl peptide chemoattractant G protein-coupled receptor family (FPR). Two
synthetic hexapeptides Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) and
Trp-Lys-Tyr-Met-Val-D-Met-NH2 (WKYMVm) specifically bind to FPRL1 and FPRL2.
Its L or D conformers also induce phosphorylation and internalization of
FPRL1. The data indicated that neutrophils are activated by WKYMVM through FPRL1
and FPRL2 is a chemotactic receptor transducing signals in myeloid cells.
Christophe, T. et al. J. Biol. Chem. online April 02, 2001
Related
Chemotactic Peptide Products
Want to visualize FPRL1 and FPRL2 dynamic trafficking in living cells?
Try fluorescent WKYMVM / WKYMVm !!!
Ac2-26 is a ligand
for Formylated Peptide Recepto
Monitoring
Formylated Peptide Receptor with Fluorescent Peptide
