From thousands of peptides from our stock, we have put together various peptide family libraries for receptor and natural ligand studies:

		Alzheimer Fingerprint Library (Updated 08/25/2011)
		GPCR Peptide Ligand Library (Updated )
		New Orphan Receptor Peptide Ligand Library (Updated )
		Chop-Suey Peptide Library (Variety Pack) (Updated )
		Opioid Peptide Library (Updated 08/25/2011)
		Obesity Peptide Libraries (Updated )
		Gastrointestinal Peptide Library (Updated )
		Brain Peptide Library (Bees) (Updated )
		Anti-angiogenic Peptide Library (Updated )
		Bioactive Secretory Peptide/Protein Library (Updated )
		Human Proteome Signature Peptide Library (Updated )
		Diabetes’ drug leads Bioactive Peptide Library (Updated )
		Custom Peptide Library

Alzheimer Fingerprint Library*
G Protein Coupled Receptor Peptide Ligand Library*:
More than 40 families of identified or suspected G Protein Coupled Receptor Peptide Ligands as well as its related agonists and antagonists enable a "reverse pharmacology approach" for large scale screening Orphan G Protein Coupled Receptors included over five hunderd peptides which are HPLC-purified and fluorescein free. This library covers various newly identified G Protein Coupled Receptor Ligands including RFamide Related Peptides (OT7T022), Neuromedin U (NmU R-1/FM-3 and NmU R-2/FM-4), human Urotensin II (GPR14), Neuropeptide AF/FF(NPFF-1 and NPFF-2), Ghrelin(GHS-Rs), Motilin(GPR-38-A), MCH(SLC-1), Orexins and Hypocretins (HFGAN-72), Prolactin Releasing Peptide (HGR-3/GPR-10/UHR-1), Orphanin FQ (ORL-1) and Apelin(APJ).

Chop-Suey Peptides Library (Variety Pack)*
Opioid Peptides Library*
Obesity Related Peptide Library*
Gastrointestinal Peptides Library*
Brain Peptide Library (Bees)
Anti-angiogenic Peptide Library
Custom Peptide Library

Phoenix's Peptide Receptor Ligand Libraries, a broad set of peptides (thousands), enables a "reverse pharmacology" approach to identify unknown membrane receptors, G-protein-coupled receptors, ion channels, intracellular signaling enzymes and receptors.Feighner et al. (1), successfully identified a human motilin receptor using the Phoenix Gastrointestinal Peptide Library and HEK293 cells in which a human motilin receptor was coexpressed with aequorin, a bioluminescent calcium sensitive reporter protein. A similar approach was taken by Chambers et al. (2), to identify an orphan G-protein coupled receptor as a human MCH receptor, using over 700 naturally occurring and putative neuropeptide's. Recently, neuromedin U has been identified as a natural ligand for two orphan G protein coupled receptors, FM-3 and FM-4.

Howard, A.D. et al. Nature 406, 70-75 (July 6, 2000)

References:

1. Feighner, S.D. et al., Science 284, 2184-2188 (1999)
2. Chambers, J. et al., Nature 400, 261-265 (1999)
3. Howard, A.D. et al.Identification of receptors for neuromedin U and its role in feeding. Nature 406, 70-75 (July 6, 2000).